Exploring public genomics data for population pharmacogenomics
نویسندگان
چکیده
منابع مشابه
Exploring public genomics data for population pharmacogenomics
Racial and ethnic differences in drug responses are now well studied and documented. Pharmacogenomics research seeks to unravel the genetic underpinnings of inter-individual variability with the aim of tailored-made theranostics and therapeutics. Taking into account the differential expression of pharmacogenes coding for key metabolic enzymes and transporters that affect drug pharmacokinetics a...
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This special report concerns a talk on data standards given at a workshop entitled 'An International Perspective on Pharmacogenetics: The Intersections between Innovation, Regulation and Health Delivery', which was held by the Organization for Economic Co-operation and Development (OECD) on October 17-19, 2005, in Rome, Italy. The worlds of healthcare and life sciences (HCLS) are extremely frag...
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mechanisms – and oversight. The needs and expectations of both clinicians and patients must be considered, and unanticipated consequences, such as the potential ‘nocebo’ effect described by Haga and colleagues [3] , must be considered. And as with other genomic research, limitations in study design or analysis may lead to overly simplistic interpretations of population differences in drug respo...
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It is timely to consider the ethical and social questions raised by progress in pharmacogenomics, based on the current importance of pharmacogenomics for avoidance of predictable side effects of drugs, and for correct choice of medications in certain cancers. It has been proposed that the entire population be genotyped for drug-metabolizing enzyme polymorphisms, as a measure that would prevent ...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2017
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0182138